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Ubu bwoko bwa kanseri yo mu gifu biragoye kubimenya, witonde rero mugihe cya endoskopi!

Mu bumenyi buzwi cyane kuri kanseri yo mu gifu hakiri kare, hari ingingo zimwe na zimwe zita ku ndwara zidasanzwe zisaba kwitabwaho no kwiga.Imwe muri zo ni kanseri yo mu nda ya HP.Igitekerezo cya "ibibyimba bitanduye byanduye" ubu birakunzwe cyane.Hazabaho ibitekerezo bitandukanye kubibazo byizina.Iyi nyigisho ikubiyemo ahanini ishingiye ku kinyamakuru "Inda n'amara", kandi iryo zina rikoresha "kanseri yo mu nda ya HP".

Ubu bwoko bwibisebe bufite ibimenyetso biranga abantu bake, ingorane zo kumenyekana, ubumenyi bwimbitse, kandi inzira yoroshye ya MESDA-G ntabwo ikoreshwa.Kwiga ubu bumenyi bisaba guhangana ningorane.

1. Ubumenyi bwibanze bwa HP-mbi ya kanseri yo mu gifu

Amateka

Mu bihe byashize, abantu bemezaga ko nyirabayazana umwe mu kubaho no gutera kanseri yo mu gifu ari indwara ya HP, bityo rero uburyo bwa kanseri yo mu bwoko bwa kanseri ni HP - atrophy - metaplasia yo mu nda - ikibyimba gito - ikibyimba kinini - kanseri.Icyitegererezo cyakera cyamenyekanye cyane, cyemewe kandi cyizerwa.Ibibyimba bikurira hamwe hashingiwe kuri atrophy no mubikorwa bya HP, bityo kanseri ahanini ikura mumyanya yo munda ya atrophique hamwe na mucosa gastrica idasanzwe.

Nyuma, abaganga bamwe bavumbuye ko kanseri yo mu gifu ishobora kubaho nubwo nta HP yanduye.Nubwo igipimo cyanduye kiri hasi cyane, birashoboka rwose.Ubu bwoko bwa kanseri yo mu gifu yitwa kanseri yo mu nda ya HP.

Hamwe no gusobanukirwa buhoro buhoro ubu bwoko bwindwara, ubushakashatsi bwimbitse hamwe nincamake byatangiye, kandi amazina ahora ahinduka.Hari mu mwaka wa 2012 hari ingingo yiswe "Kanseri yo mu gifu nyuma ya Sterilisation", ingingo yo mu 2014 yiswe "Kanseri yo mu nda ya HP-mbi", n'ingingo yo muri 2020 yitwa "Ibibyimba bya Epitheliya bitanduye Hp".Guhindura izina byerekana ubushishozi bwimbitse kandi bwuzuye.

Ubwoko bwa Gland nuburyo bwo gukura

Hariho ubwoko bubiri bwibanze bwa glande na pyloric gland mu gifu:

Imvubura zifatika (glande oxyntique) zitangwa mu kigega, umubiri, inguni, nibindi byigifu.Ni umurongo umwe wigituba.Zigizwe na selile selile, selile selile, parietal selile na endocrine selile, buriwese ukora imirimo yawo.Muri byo, ingirabuzimafatizo zikomeye PGI na MUC6 zasohotse zari nziza, kandi selile parietal zasohoye aside hydrochloric nibintu byinjira;

Imvubura za pyloric ziherereye mu gice cya antrum gastric kandi zigizwe na selile selile na endocrine selile.Mucus selile ni MUC6 nziza, naho selile endocrine zirimo G, D selile na enterochromaffin.G selile isohora gastrine, D selile isohora somatostatine, na enterochromaffin selile isohora 5-HT.

Ingirabuzimafatizo zisanzwe zo mu nda hamwe na selile yibibyimba zisohora ubwoko butandukanye bwa poroteyine zo mu bwoko bwa mucus, zigabanyijemo poroteyine "gastric", "amara" na "ivanze".Imvugo yo mu gifu no mu mara yitwa fenotype kandi ntabwo ari ahantu hihariye h'igifu n'amara.

Hano hari selile enye za fenotipi yibibyimba byo munda: gastrica rwose, gastric-yiganje ivanze, amara-yiganjemo amara, kandi amara rwose.Ibibyimba bibaho bishingiye kuri metaplasia yo munda ahanini ni gastrointestinal ivanze na fenotype yibibyimba.Kanseri zitandukanye zerekana ahanini ubwoko bw'amara (MUC2 +), kandi kanseri ikwirakwiza yerekana ubwoko bwa gastric (MUC5AC +, MUC6 +).

Kumenya Hp mbi bisaba guhuza uburyo bwinshi bwo gutahura kugirango tumenye neza.Kanseri yo mu nda ya HP na kanseri yo mu gifu nyuma yo kubagwa ni ibintu bibiri bitandukanye.Ukeneye ibisobanuro birambuye kuri X-yerekana kanseri yo mu gifu ya HP-mbi, nyamuneka reba igice kijyanye n'ikinyamakuru "Inda n'amara".

2. Endoskopi igaragara ya HP-mbi ya kanseri yo mu gifu

Kwipimisha Endoscopique nibyo byibandwaho na kanseri yo mu nda ya HP.Harimo ahanini kanseri yo mu bwoko bwa kanseri yo mu gifu, kanseri yo mu bwoko bwa gland mucosal, kanseri yo mu gifu, adenoma gastric, raspberry foveolar epithelial tumor, signet ring selile carcinoma, nibindi. Iyi ngingo yibanze kuri endoskopi igaragara ya kanseri yibasira HP.

1) Indwara ya kanseri yo mu bwoko bwa kanseri yo mu gifu

-Abazungu bazamuye ibikomere 

kanseri yo mu bwoko bwa kanseri yo mu gifu

1 (1)

◆ Urubanza 1: Ibikomere byera, bizamuye

Ibisobanuro:Gastric fundic fornix-nini cyane ya curvature yumutima, mm 10, umweru, ubwoko bwa O-lia (SMT-isa), idafite atrophy cyangwa metaplasia yo munda inyuma.Imiyoboro y'amaraso imeze nka Arbor irashobora kugaragara hejuru (NBI no kwaguka gato)

Gusuzuma (bihujwe na patologiya):U, O-1la, 9mm, ubwoko bwa kanseri yo mu bwoko bwa kanseri yo mu gifu, pT1b / SM2 (600μm), ULO, Ly0, VO, HMO, VMO

-Ibisebe byera

kanseri yo mu bwoko bwa kanseri yo mu gifu

1 (2)

Urubanza 2: Ibikomere byera, biringaniye / byihebye

Ibisobanuro:Urukuta rw'imbere rwa gastric fundic fornix-cardia igoramye cyane, mm 14, umweru, andika 0-1lc, idafite metroplasia ya atrophy cyangwa amara inyuma, imipaka idasobanutse, hamwe nimiyoboro y'amaraso ya dendritic igaragara hejuru.(NBI na amplification mu magambo ahinnye)

Gusuzuma (bihujwe na patologiya):U, 0-Ilc, 14mm, ubwoko bwa gland bwubwoko bwa kanseri yigifu, pT1b / SM2 (700μm), ULO, Ly0, VO, HMO, VMO

-Ibisebe byazamuye ibikomere

kanseri yo mu bwoko bwa kanseri yo mu gifu

1 (3)

◆ Urubanza 3: Ibikomere bitukura kandi bizamuye

Ibisobanuro:Urukuta rwimbere rwikigero kinini cyumutima ni mm 12, biragaragara ko rutukura, andika 0-1, nta na atrophy cyangwa metaplasia yo munda inyuma, imipaka isobanutse, hamwe nimiyoboro yamaraso ya dendritic hejuru (NBI no kwaguka gato)

Gusuzuma (bihujwe na patologiya):U, 0-1, 12mm, ubwoko bwa gland bwubwoko bwa kanseri yigifu, pT1b / SM1 (200μm), ULO, LyO, VO, HMO, VMO

-Umutuku, uringaniye, wihebyes

kanseri yo mu bwoko bwa kanseri yo mu gifu

1 (4)

. Urubanza rwa 4: Ibikomere bitukura, biringaniye / byihebye

Ibisobanuro:Urukuta rw'inyuma rw'igabanuka rinini ry'igice cyo hejuru cy'umubiri wa gastric, 18mm, umutuku werurutse, O-1Ic, nta atrophy cyangwa metaplasia yo mu nda inyuma, imbibi zidasobanutse neza, nta miyoboro y'amaraso ya dendritic iri hejuru, (NBI no kwaguka byasibwe )

Gusuzuma (bihujwe na patologiya):U, O-1lc, 19mm, ubwoko bwa kanseri yo mu bwoko bwa kanseri yo mu gifu, pT1b / SM1 (400μm), ULO, LyO, VO, HMO, VMO

muganire

Abagabo bafite iyi ndwara bakuze kurusha igitsina gore, impuzandengo yimyaka 67.7.Bitewe n'ibiranga icyarimwe hamwe na heterochrony, abarwayi basuzumwe kanseri yo mu bwoko bwa kanseri yo mu gifu bagomba gusubirwamo rimwe mu mwaka.Ikibanza gikunze kugaragara cyane ni agace ka fondasiyo yo hagati mugice cyo hejuru no hejuru cyigifu (fundus nigice cyo hagati nigice cyo hejuru cyumubiri wa gastric).Ibara ryera rya SMT risa n'ibikomere bikunze kugaragara mumucyo wera.Ubuvuzi nyamukuru nugusuzuma EMR / ESD.

Nta lymphatic metastasis cyangwa gutera imitsi byagaragaye kugeza ubu.Nyuma yo kuvurwa, birakenewe kumenya niba wongeye kubagwa no gusuzuma isano iri hagati yimiterere mibi na HP.Kanseri yo mu bwoko bwa kanseri yo mu bwoko bwa kanseri ntabwo ari HP mbi.

1) Kanseri yibanze ya glande mucosal

Inkunga ya gland mucosal kanseri yo mu gifu

1 (5)

◆ Urubanza 1

Ibisobanuro:Indwara yazamutse gato, kandi RAC itari mucye ya gastric mucosa irashobora kugaragara hafi yayo.Guhindura byihuse microstructure na microvessels birashobora kugaragara mugice cyazamuye cya ME-NBI, kandi DL irashobora kuboneka.

Gusuzuma (bihujwe na patologiya):Indwara ya gland mucosal kanseri yo mu gifu, U zone, 0-1la, 47 * 32mm, pT1a / SM1 (400μm), ULO, Ly0, VO, HMO, VMO

Inkunga ya gland mucosal kanseri yo mu gifu

1 (6)

◆ Urubanza 2

Ibisobanuro.

Gusuzuma (bihujwe na patologiya): Inkunga ya gland mucosal kanseri yo mu gifu, 0-lla, pT1a / M, ULO, LyOV0, HM0, VMO

muganire

Izina rya "gastric gland mucosal adenocarcinoma" biragoye kuvuga, kandi umubare w'abanduye ni muto cyane.Bisaba imbaraga nyinshi zo kubimenya no kubyumva.Inkunga ya gland mucosal adenocarcinoma ifite ibiranga ububi bukabije.

Hano haribintu bine byingenzi biranga urumuri rwera endoskopi: ① ibikomere bya homochromatic-fading;Tumor ikibyimba cya subepithelia SMT;③ yaguye imiyoboro y'amaraso ya dendritic;Mic microparticles yo mu karere.ME imikorere: DL (+) IMVP (+) IMSP (+) MCE yagura IP ikiyongera.Ukoresheje uburyo bwa MESDA-G bwasabwe, 90% ya kanseri ya glande mucosal kanseri yo mu gifu yujuje ibisabwa.

3) Gastrici adenoma (pyloric gland adenoma PGA)

gastric adenoma

1 (7)

◆ Urubanza 1

Ibisobanuro:Igorofa yera yazamuye igikomere cyagaragaye kurukuta rwinyuma rwa gastric fornix ifite imbibi zidasobanutse.Indimu ya carmine yerekana nta mbibi zisobanutse, kandi LST-G isa n amara manini yagaragaye (yagutse gato).

Gusuzuma (bihujwe na patologiya):kanseri ya atypia nkeya, O-1la, 47 * 32mm, itandukanijwe neza na tubular adenocarcinoma, pT1a / M, ULO, Ly0, VO, HMO, VMO

gastric adenoma

1 (8)

◆ Urubanza 2

Ibisobanuro: Indwara yazamuye hamwe na node ku rukuta rw'imbere rw'igice cyo hagati cy'umubiri wa gastric.Gastrite ikora irashobora kugaragara inyuma.Indigo carmine irashobora kugaragara nkumupaka.(NBI no gukuza gato)

Inzobere: Imvugo ya MUC5AC yagaragaye muri epitelium yimbere, naho MUC6 imvugo yagaragaye muri epitelium yimbere.Isuzuma rya nyuma ni PGA.

muganire

Adenoma yo mu gifu ni glande ya mucinous yinjira muri troma kandi itwikiriwe na epitelium ya foveolar.Bitewe no gukwirakwira kwa glandular, ari hemispherical cyangwa nodular, adenoma gastrica igaragara hamwe nurumuri rwera rwa endoskopi byose ni nodular kandi birasohoka.Birakenewe kwitondera ibyiciro 4 bya Jiu Ming mugupima endoskopi.ME-NBI irashobora kureba ibiranga papillary / isura mbi ya PGA.PGA ntabwo ari HP mbi rwose kandi ntabwo ari atrophike, kandi ifite ibyago bimwe byo guhagarikwa.Gusuzuma hakiri kare no kuvurwa hakiri kare birashyigikirwa, kandi nyuma yo kuvumburwa, gukora en bloc resection hamwe nubushakashatsi burambuye birasabwa.

4) (raspberry-imeze) foveolar epithelial kanseri yo mu gifu

raspberry foveolar epithelial kanseri yo munda

1 (10)

◆ Urubanza 2

Ibisobanuro:(usibye)

Gusuzuma (bihujwe na patologiya): foveolar epithelial kanseri yo mu gifu

raspberry foveolar epithelial kanseri yo munda

1 (11)

◆ Urubanza 3

Ibisobanuro:(usibye)

Gusuzuma (bihujwe na patologiya):foveolar epithelial kanseri yo mu gifu

muganire

Raspberry, yitwa "Tuobai'er" mu mujyi w'iwacu, ni imbuto zo mu gasozi ku muhanda igihe twari tukiri abana.Epitelium ya glandular na glande birahujwe, ariko ntabwo biri mubintu bimwe.Birakenewe gusobanukirwa imikurire niterambere biranga selile.Raspberry epithelial kanseri yo mu gifu isa cyane na polyps gastric kandi irashobora kwibeshya byoroshye kuri polyps gastric.Ikiranga epitelium ya foveolar nigaragaza cyane MUC5AC.Foveolar epithelial carcinoma nijambo rusange kuri ubu bwoko.Irashobora kubaho muri HP mbi, nziza, cyangwa nyuma yo kuboneza urubyaro.Endoskopi igaragara: izengurutse ibara ritukura rya strawberry-isa nini, muri rusange ifite imipaka isobanutse.

5) Umukono w'impeta kanseri

Umukono impeta ya selile kanseri: urumuri rwera

1 (12)

Umukono impeta ya selile kanseri: urumuri rwera

1 (13)

umukono impeta ya kanseri

1 (14)

◆ Urubanza 1

Ibisobanuro:Flat lesion kurukuta rwinyuma rwa gastric vestibule, mm 10, yazimye, andika O-1Ib, nta atrophy inyuma, umupaka ugaragara mbere, ntabwo umupaka ugaragara kubisubiramo, ME-NBI: gusa igice cyimbere gihinduka umweru, IMVP (-) IMSP (-)

Gusuzuma (bihujwe na patologiya):Ingero za ESD zikoreshwa mugupima ibimenyetso bya selile kanseri.

Kugaragaza indwara

Isinya impeta ya selile kanseri nubwoko bubi cyane.Dukurikije ibyiciro bya Lauren, ibimenyetso byerekana ibimenyetso byerekana kanseri ya kanseri yashyizwe mu bwoko bwa kanseri ikwirakwizwa kandi ni ubwoko bwa kanseri itandukanye.Bikunze kugaragara mu mubiri wigifu, kandi bikunze kugaragara mubikomere byoroshye kandi byacitse hamwe nijwi ryamabara.Ibikomere byazamutse ni gake kandi birashobora no kugaragara nk'isuri cyangwa ibisebe.Biragoye kubimenya mugihe cyo kwisuzumisha endoskopi mugihe cyambere.Umuti urashobora kuvura indwara nka endoskopique ESD, hamwe no gukurikiranwa nyuma yo kubagwa no gusuzuma niba ugomba kubagwa byongeye.Kudakira bidakira bigomba gusaba kubagwa byongeye, kandi uburyo bwo kubaga bwemezwa nabaganga babaga.

Inyigisho hamwe namashusho yavuzwe haruguru biva kuri "Inda n'amara"

Byongeye kandi, hakwiye kandi kwitabwaho kanseri ifata Esophagogastric, kanseri yumutima, na adenocarcinoma itandukanye cyane iboneka inyuma ya HP.

3. Incamake

Uyu munsi namenye ubumenyi bujyanye no kwerekana endoskopique ya kanseri yo mu nda ya HP.Harimo cyane cyane: kanseri yo mu bwoko bwa kanseri yo mu gifu, kanseri yo mu bwoko bwa gland mucosal, kanseri yo mu gifu, adenoma yo mu gifu, (raspberry-imeze) foveolar epithelial ikibyimba na kanseri y'impeta ya kanseri.

Indwara ya kanseri yo mu gifu ya HP-mbi ni mike, biragoye guca imanza, kandi biroroshye kubura kwisuzumisha.Ikirushijeho kuba ingorabahizi ni kwigaragaza kwa endoskopi yindwara zikomeye kandi zidasanzwe.Bikwiye kandi kumvikana duhereye kuri endoskopi, cyane cyane ubumenyi bwa teoretiki inyuma yacyo.

Niba urebye polyps gastric, isuri, hamwe nuduce dutukura nuwera, ugomba gutekereza ko bishoboka kanseri ya Hp-mbi.Urubanza rwa HP rugomba kubahiriza ibipimo, kandi hagomba kwitonderwa ibibi biterwa no kwishingikiriza cyane kubisubizo byikizamini.Inararibonye ya endoskopiste yizera amaso yabo cyane.Guhangana nigitekerezo kirambuye inyuma ya HP-mbi ya kanseri yo mu gifu, tugomba gukomeza kwiga, gusobanukirwa no kwitoza kubimenya.

Twebwe, Jiangxi Zhuoruihua Medical Instrument Co., Ltd., Ni uruganda mu Bushinwa ruzobereye mu gukoresha endoskopi, nkabiopsy imbaraga, hemoclip, umutego, inshinge, spray catheter, cytology,kuyobora,igitebo cyo kugarura amabuye, izuru biliary drainage catheter nibindi.zikoreshwa cyane muriEMR,ESD,ERCP.Ibicuruzwa byacu byemewe na CE, kandi ibihingwa byacu byemewe na ISO.Ibicuruzwa byacu byoherejwe mu Burayi, Amerika y'Amajyaruguru, Uburasirazuba bwo hagati ndetse no muri Aziya, kandi bigera ku bakiriya bamenyekana kandi bashimwe!


Igihe cyo kohereza: Nyakanga-12-2024